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As part of the PI's outreach, a course-based undergraduate research experience engaged undergraduate women in research from examining the literature to identify a gap, formulating a research hypothesis, designing experiments to test the hypothesis, analyzing the data, writing and submitting an abstract and presenting the research to the scientific community. This project was as follows: in the US, 5 million people require blood transfusions each year. Although generally safe, there are drawbacks to blood transfusions including fever, acute immune or delayed hemolytic reactions, anaphylactic reactions, transfusion related acute lung injury, and bloodborne infections. Despite screening for diseases such as HIV and hepatitis, the risk of contraction is nonzero, and there are continually emerging bloodborne diseases such as Zika that are not yet screened for. Additionally, there are often blood bank shortages. These complications have driven decades of research into artificial blood, yet to date there are no blood substitutes clinically available. While hemoglobin based oxygen carriers have shown promise, they also show oxidative damage to tissues, particularly in cardiac and renal tissues. Both high and low oxygen PEGylated hemoglobin (Hb) have shown such oxidative stress. We hypothesized that this oxidative stress was due to direct delivery of the PEGylated Hb and conjugated PEGylated Hb onto PEG hydrogel microspheres. In this study, we probed the ability of the Hb microspheres to deliver oxygen.more » « less
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A high frequency solid-state transformer (SST) proposed by FREEDM centre is an interesting alternative to conventional distribution transformer in microgrids as it supports additional functionalities such as active-reactive power flow control, fault current limitation and voltage regulation. This paper proposes a dynamic phasor based robust control of SST through the modular control of each stage. The control problem is formulated in frequency domain by representing the system states with time varying Fourier coefficients or dynamic phasors (DP). This formulation transforms the oscillating waveforms of ac circuits to constant or slowly varying variables, hence allow the use of PI controller to track the sinusoidal references. For rectifier and inverter stages of SST, dq transformation is applied on DP which facilitates the design of PI controller to smoothen out the ripples in the output voltage waveform. The controller gains are tuned to reject input and load disturbances and attenuate measurement noise using loop shaping and pole assignment technique. The robustness of the controller is assured analytically against parametric uncertainties using small gain theorem. Simulation results are provided to support the proposed control scheme. Hardwarein- Loop (HIL) simulation is carried out on critical stages using Opal-RT and dSPACE simulators to confirm the effectiveness of the proposed scheme.more » « less
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Abstract The Gravitational-Wave Transient Catalog (GWTC) is a collection of short-duration (transient) gravitational-wave signals identified by the LIGO–Virgo–KAGRA Collaboration in gravitational-wave data produced by the eponymous detectors. The catalog provides information about the identified candidates, such as the arrival time and amplitude of the signal and properties of the signal’s source as inferred from the observational data. GWTC is the data release of this dataset, and version 4.0 extends the catalog to include observations made during the first part of the fourth LIGO–Virgo–KAGRA observing run up until 2024 January 31. This Letter marks an introduction to a collection of articles related to this version of the catalog, GWTC-4.0. The collection of articles accompanying the catalog provides documentation of the methods used to analyze the data, summaries of the catalog of events, observational measurements drawn from the population, and detailed discussions of selected candidates.more » « lessFree, publicly-accessible full text available December 9, 2026
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A first search for beyond the standard model physics in jet multiplicity patterns of multilepton events is presented, using a data sample corresponding to an integrated luminosity of of 13 TeV proton-proton collisions recorded by the CMS detector at the LHC. The search uses observed jet multiplicity distributions in one-, two-, and four-lepton events to explore possible enhancements in jet production rate in three-lepton events with and without bottom quarks. The data are found to be consistent with the standard model expectation. The results are interpreted in terms of supersymmetric production of electroweak chargino-neutralino superpartners with cascade decays terminating in prompt hadronic -parity violating interactions.more » « lessFree, publicly-accessible full text available December 1, 2026
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